Common Side Effects of GLP-1s — and How to Manage Them 📝
GLP-1 medications like Semaglutide and Tirzepatide have become powerful tools for sustainable weight management, improved metabolic health, and better blood sugar control. While the results can be life-changing, it’s completely normal to experience some side effects as your body adjusts.
At Bio-tique, our goal is to support you through every phase of your wellness journey — including understanding what’s normal, what’s temporary, and what simple steps can help you feel your best.
Common Side Effects
Below are the most commonly reported side effects and what may cause them:
1. Nausea
This is the most common side effect when starting or increasing your dose. GLP-1s slow down gastric emptying, which can make you feel full quickly or trigger mild nausea.
2. Fatigue or Low Energy
Your body is adjusting to a slower digestive process and more efficient blood sugar regulation. This change can temporarily affect energy levels.
3. Constipation
Because digestion slows down on GLP-1s, constipation is a frequent early experience.
4. Heartburn or Reflux
Some clients notice reflux due to slower movement of food through the stomach.
5. Decreased Appetite
While often a benefit, it can also make hitting protein and hydration goals more challenging.
How to Manage Side Effects
🍽 Eat Slowly & Stop at First Signs of Fullness
Overeating — even small amounts — can trigger nausea or reflux. Light, balanced meals work best while adjusting.
💧 Stay Hydrated
Aim for at least 64 oz of water daily. Add electrolytes to support digestion and energy, especially on days you feel sluggish.
🥗 Focus on Protein First
Protein maintains muscle, supports metabolism, and helps stabilize blood sugar. Start meals with your protein source, then add veggies and healthy fats.
🚶♀️ Gentle Movement Helps
Walking after meals supports digestion, reduces nausea, and helps with constipation.
🫖 Ginger, Peppermint, or Warm Herbal Tea
These can ease nausea and bloating naturally.
🥦 Fiber + Magnesium for Digestion
Fiber (from veggies or supplements) and magnesium citrate or glycinate can help with regularity. Start slowly to avoid adding more bloating.
⚖️ Follow a Slow, Steady Dosing Schedule
Increasing too quickly can intensify side effects. At Bio-tique, we monitor your progress closely to ensure dosing supports your goals without overwhelming your system.
📞 Communicate With Your Provider
You are not alone in this — reach out anytime if something feels uncomfortable or unusual. We’re here to adjust your plan when needed.
When to Contact Your Provider
Call us if you experience:
Persistent vomiting
Severe abdominal pain
Signs of dehydration
Inability to eat or drink for more than 24 hours
These may require a dosing pause or evaluation.
The Bottom Line
Side effects are common, temporary, and manageable — especially with the right support. Almost all clients notice that symptoms ease significantly after the first few weeks or after a dose stabilizes. Our team at Bio-tique is here to guide you every step of the way with personalized care, hydration support, and nutrition guidance.
If you’re starting or currently on a GLP-1 program and have questions, don’t hesitate to reach out. Your wellness journey is unique, and we’re honored to support you through it.
